Within-person variation was unaffected by dialysis modality, hydration status, inflammation, or cardiac comorbidity. Respective between- and within-person coefficients of variation were 153% and 27% for weekly measurements, and 148% and 35% for monthly measurements. Results showed that 22% had ischemic heart disease 9% and 87% had left ventricular systolic and diastolic dysfunction, respectively. This study analyzed 136 weekly and 113 monthly NT-proBNP measurements from 40 and 41 stable patients, respectively. Patients were excluded if they became unstable. Assessments were conducted at the same time in the dialysis cycle and entailed NT-proBNP testing, clinical review, electrocardiography, and bioimpedance spectroscopy. The aims of this prospective cohort study were to estimate the within- and between-person coefficients of variation of NT-proBNP in stable dialysis patients, and derive the critical difference between measurements needed to exclude biologic and analytic variation.įifty-five prevalent hemodialysis and peritoneal dialysis patients attending two hospitals were assessed weekly for 5 weeks and then monthly for 4 months between October 2010 and April 2012.
#Spector pro monitoring for terminal server serial
However, its biologic variation is unknown, hindering the accurate interpretation of serial concentrations. Monitoring N-terminal pro-B-type natriuretic peptide (NT-proBNP) may be useful for assessing cardiovascular risk in dialysis patients.
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